Sacramento Invokana® Ketoacidosis Injury Lawyers
The Arnold Law Firm is investigating Invokana and other diabetes medications containing the drug canagliflozin, on behalf of individuals who were prescribed these drugs and experienced ketoacidosis, kidney failure, or foot or leg amputation.
If you were prescribed Invokana, Invokamet, Invokamet XR or any other SGLT2 inhibitor, and have experienced serious medical issues, you may be entitled damages for your suffering. Our Sacramento dangerous drug attorneys have a strong background in class action lawsuits and holding pharmaceutical companies accountable for selling dangerous drugs to consumers. We will review your claim through a free, no obligation consultation to determine if you can pursue legal action against Invokana’s manufacturers. All of our services are provided at no upfront cost. You only pay if we recover damages for your claim.
Call our legal professionals for a free case review. (916) 777-7777.
What is Invokana?
Invokana is a brand name of the drug canaglifozin, a sodium-glucose contransporter-2 (SGLTC2) inhibitor prescribed to patients diagnosed with type 2 diabetes.
Canaglifozin was designed to inhibit kidney function to reduce the levels of glucose (sugar) in the blood stream.
Those with type 2 diabetes are insulin resistant, which means their blood cells cannot utilize the hormone insulin to convert glucose (sugar) into energy. This causes the body’s blood sugar levels to be elevated, which can lead to kidney, eye, nerve and heart damage.
To reduce blood sugar levels, canaglifozin prevents the kidney from depositing glucose into the blood stream like it normally would. Instead, the drug removes excess sugar through urination.
However, this process has produced several dangerous side effects.
Medical Problems Caused by Invokana
Since Invokana was released into the market in 2013, many people have reported serious medical complications after taking the drug. These side effects include:
- Kidney impairment
- Urinary tract infections
- Bone problems
- Potentially fatal cardiovascular events, like heart attack or stroke
This is despite claims from the makers of Invokana, Janssen Pharmaceutical, Inc., a Johnson & Johnsons subsidiary, that the drug is safe for all users and has few harmful side effects.
However, numerous patients who were prescribed Invokana have developed serious health complications.
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Diabetic ketoacidosis (DKA) is a life-threatening condition that forms when the body’s cells are deprived of the glucose needed to produce energy because there is not enough insulin.
When cells cannot receive sugar for energy, the body replaces it by breaking down fat and muscle for energy. This produces fatty acids called ketones, which enter the bloodstream and can lead to a harmful level of acids in the blood.
Early signs of DKA include persistent feelings of thirst and frequent urination. High blood sugar levels and high levels of ketones in a patient’s urine are also indicators of the condition.
Urgent diabetic ketoacidosis symptoms that require prompt medical attention include:
- Nausea, vomiting or pain in abdomen
- Difficulty breathing
- Fruity odor on breath
- Confusion or distraction
The effects of DKA are severe and increase the possibility of the patient experiencing coma or death.
FDA Warns Invokana Could Cause DKA
On May 5, 2015, the FDA released a safety alert stating that Invokana and similar diabetes medications have been linked to ketoacidosis.
At the time the FDA issued its warning, the agency had received at least 20 reports of ketoacidosis in patients who were prescribed diabetes drugs from the SGLT2 inhibitor class, including Invokana.
As of May 2017, approximately 73 cases of ketoacidosis were reported to the FDA's Adverse Event Reporting System (FAERS) between March 2013 and May 2015.
In December 2016, the FDA required manufacturers of SGLT2 inhibitors to change the label to include warnings that the drug could cause excessive levels of acid in the blood.
The label change also required warnings that SGLT2 inhibitors can increase the risk of urinary tract infection due to glucose being deposited through the urinary system.
Invokana’s interference with kidney function has also been found to drastically increase the risk of acute kidney injury.
Acute kidney injuries occur when the organs suddenly shut down and stop working. This can cause dangerous levels of waste to build in the body.
Symptoms of acute kidney failure can include decreased urine or swelling in the legs or feet. Patients who experience signs of acute kidney failure after taking Invokana should immediately consult a doctor.
However, patients should not stop taking Invokana or other brands of canaglifozin without first consulting with a medical professional. This could lead to uncontrolled and potentially harmful glucose levels.
FDA Warns about Invokana’s Link to Kidney Damage
On June 6, 2016, the FDA strengthened its existing warning about the high risk of kidney damage among users of canaglifozin.
The updated warning was issued in response to 101 confirmed reports of acute kidney injuries between Invokana’s release in March 2013 and October 2015. Some of these victims required hospitalization and dialysis.
In approximately half of the confirmed cases, the injury occurred within the first month of using the drug.
The FDA now requires manufacturers of canaglifozin to include a revised warning label on the drug’s container that includes information about acute kidney injury and recommendations to minimize this risk.
Foot and Leg Amputation
In 2016, the Canaglifozin Cardiovascular Assessment Study (CANVAS) analyzed the side effects experienced by patients taking canaglifozin to treat type 2 diabetes.
The trial’s independent researchers found that patients treated with canaglifozin faced an increased risk of foot or leg amputation two times higher than those who were administered a placebo.
An interim analysis of the study showed that more than one year’s use of the drug led participants to experience the following risk of amputation:
- 7 out of every 1,000 patients treated with 100 mg daily of canaglifozin
- 5 out of every 1,000 patients treated with 300 mg daily of canaglifozin
- 3 out of every 1,000 patients treated with placebo
Based on the interim data collected in the clinical trial, the FDA issued a warning in May 2016 informing the public that Invokana can double the risk of amputation. It then confirmed that finding in an updated safety warning on May 16, 2017.
The FDA warned that patients taking Invokana could develop pain or tenderness, sores, ulcers, or infections in their feet or legs. These symptoms could be an early indication that the patient requires amputation.
According to the FDA, the most common amputation was of the patient’s toes or middle of the foot. There were also several incidences in which the patient’s leg required amputation above or below the knee. Some patients also required both limbs to be amputated, however this result was rare.
Call (916) 777-7777 to learn if you are entitled to file an Invokana lawsuit.
SGLTC2 Manufacturers May Have Known About Deadly Side Effects
Many patients who have experienced these dangerous side effects have filed Invokana lawsuits against Janssen Pharmaceutical Inc., claiming that the company knew about the potential side effects caused by these drugs and purposely withheld the information from public knowledge.
The consumer protection group Institute of Safe Medication Practices (ISMP) has linked Invokana to more than 400 severe adverse events that occurred within the first 12 months of its market release in 2013. Some of those adverse events include:
- Kidney failure or impairment: 54 events
- Dehydration and fluid imbalances: 54 events
- Kidney stones: 11 events
- Urinary tract infections: 50 events
- Abnormal weight loss: 52 events
Call (916) 777-7777 to speak with our attorneys about an Invokana lawsuit.
Contact Our Sacramento Invokana Ketoacidosis Lawyers
If you have suffered serious side effects after taking Invokana, Invokamet or Invokamet XR you may be able to recover damages for your pain and suffering by filing an Invokana lawsuit against Janssen Pharmaceutical, Inc.
Our team of Sacramento defective drug lawyers is compassionate to victims of defective drugs and strongly believes that companies and corporations must be held responsible and accountable for their negligent actions.
At the Arnold Law Firm, your initial case review is free and we will fight to obtain the maximum compensation you are entitled to receive. We only work on a contingency fee basis, which means our attorneys will only charge you if we obtain a recovery or settlement for your claim.